GENETIC POLYMORPHISMS OF THE A AND B SUBUNITS OF COAGULATION FACTOR-XIII IN THE CHINESE POPULATION

Coagulation factor XIIIA and XIIIB polymorphisms in a random populatio n sample from Chengdu in southwest China (n = 121) were studied using isoelectric focusing in polyacrylamide gels followed by immunoblotting with enzyme immunoassay. The allele frequencies were as follows: FXII IA1 = 0.8719, FXIIIA*2 = 0.1240, FXIIIA*3 = 0.0041; FXIIIB*1 = 0.2727 , FXIIIB2 = 0.0 1 65, FXIIIB*3 = 0.7107. The distribution of phenotyp es of FXIII agrees with the Hardy-Weinberg equilibrium. Comparing thes e allele frequencies with those reported in other populations, it was found that the allele frequencies of FXIIIA1 and FXIIIB*3 in the Chin ese population were higher.