IDENTIFICATION OF A NEW DNA POLYMORPHISM TIGHTLY LINKED TO DQ-ALPHA LOCUS

Authors
GASPARINI P BONIZZATO A TOTARO A ZELANTE L
Citation
P. Gasparini et al., IDENTIFICATION OF A NEW DNA POLYMORPHISM TIGHTLY LINKED TO DQ-ALPHA LOCUS, Experimental and clinical immunogenetics, 10(3), 1993, pp. 176-178
Citations number
5
Categorie Soggetti
Genetics & Heredity",Immunology,Biology
Journal title
Experimental and clinical immunogenetics → ACNP
ISSN journal
02549670
Volume
10
Issue
3
Year of publication
1993
Pages
176 - 178
Database
ISI
SICI code
0254-9670(1993)10:3<176:IOANDP>2.0.ZU;2-L
Abstract
Utilizing Alu-polymerase chain reaction and single-strand conformation polymorphism technologies a new DNA restriction fragment length polym orphism was detected on a cosmid clone located on chromosome 6p21. An accurate analysis of allele frequency was carried out on a large serie s of unrelated individuals. Furthermore a detailed linkage analysis in several large pedigrees showed this new polymorphism to be tightly li nked to the HLA-DQalpha locus.