This article explores the evolution of regulatory federalism by examin
ing the shifting basis of disability rights mandates from conditions-o
f-aid to federal preemption. It also examines the disability rights ma
ndates placed on state and local governments by the Americans with Dis
abilities Act (ADA) and compares them with those provided in earlier f
ederal laws. The central thesis is that by adopting a preemptive appro
ach, the U.S. Congress claimed for itself the dominant role increasing
and enforcing nondiscrimination mandates to protect the rights of peo
ple with disabilities. While several organizing principles and impleme
ntation directives stipulated in ADA were first devised in earlier fed
eral laws and administrative regulations, their application through fe
deral preemption strengthened the force and reach of disability rights
protections. In the process preemption substantially reduced the auth
ority of state and local governments to create and implement their own
disability rights measures.