STREPTOMYCES-LIVIDANS AS HOST FOR HETEROLOGOUS PROTEIN-PRODUCTION

Streptomycetes are Gram-positive soil bacteria with a well differentia ted morphology. They are considered interesting candidates for the pro duction of heterologous proteins for several reasons, including their efficient secretion mechanism by which the secreted proteins are local ized into the culture supernatant. In view of this potential, this rev iew article describes different aspects of gene expression and regulat ion in Streptomyces, and summarizes and discusses results obtained usi ng Streptomyces lividans as host for secretion of heterologus proteins of prokaryotic and eukaryotic origin.