APAMIN INCREASES NMDA-INDUCED BURST-FIRING OF RAT MESENCEPHALIC DOPAMINE NEURONS

Authors
SEUTIN V JOHNSON SW NORTH RA
Citation
V. Seutin et al., APAMIN INCREASES NMDA-INDUCED BURST-FIRING OF RAT MESENCEPHALIC DOPAMINE NEURONS, Brain research, 630(1-2), 1993, pp. 341-344
Citations number
26
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
630
Issue
1-2
Year of publication
1993
Pages
341 - 344
Database
ISI
SICI code
0006-8993(1993)630:1-2<341:AINBOR>2.0.ZU;2-6
Abstract
Intracellular recordings made in vitro from rat midbrain dopamine neur ons showed that apamin (100 nM) did not alter the regular spontaneous firing of the neurons, but it increased the occurrence of bursts of ac tion potentials in N-methyl-D-aspartate. Apamin appeared to facilitate burst-firing induced by NMDA because, by blocking an outward calcium- activated potassium current, it increased the depolarizing action of N MDA.