EFFECT OF CERULETIDE ON EPILEPTOGENESIS IN AMYGDALOID-KINDLED RATS

Authors
YAMAMOTO Y ITANO T MIYAMOTO O TOKUDA M MATSUI H JANJUA NA SUWAKI H OKADA Y NEGI T MURAKAMI TH HATASE O
Citation
Y. Yamamoto et al., EFFECT OF CERULETIDE ON EPILEPTOGENESIS IN AMYGDALOID-KINDLED RATS, Brain research, 630(1-2), 1993, pp. 353-356
Citations number
24
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
630
Issue
1-2
Year of publication
1993
Pages
353 - 356
Database
ISI
SICI code
0006-8993(1993)630:1-2<353:EOCOEI>2.0.ZU;2-P
Abstract
The inhibitory effects of ceruletide (CLT), a cholecystokinin-8 (CCK)- like peptide, were investigated in the epileptogenesis in the amygdalo id kindled rats. Lower doses of CLT (20-80 mug/kg) inhibited the progr ession of kindling process. After acquiring C5 stage, a higher dose (1 60 mug/kg) was required to suppress the seizure susceptability. These results, in light of several previous studies showing no serious side effects, suggest that CLT might be useful as an anti-epileptogenic age nt for clinical usage.