Y. Nishiuchi et al., SYNTHESIS OF GAMMA-CARBOXYGLUTAMIC ACID-CONTAINING PEPTIDES BY THE BOC STRATEGY, International journal of peptide & protein research, 42(6), 1993, pp. 533-538
Gamma-Carboxyglutamic acid (Gla) derivatives having several protecting
groups at the gamma-carboxyl function were synthesized and examined f
or their stabilities and removabilities under the conditions used in p
eptide synthesis by the Boc strategy. Among them, the cyclohexyl (cHx)
group of the Gla residue was found to be stable during the synthesis
of the protected peptides, but was quantitatively cleaved by the final
HF treatment without decarboxylation. Using Boc-Gla(OcHX)2-OH as a st
arting material, the synthesis of Gla-containing peptides was achieved
by the Boc strategy using a standard HF procedure for the final depro
tection. (C) Munksgaard 1993.