CYCLOPHOSPHAMIDE-INDUCED HEPATOTOXICITY IN A PATIENT WITH WEGENERS GRANULOMATOSIS

Authors
SNYDER LS HEIGH RI ANDERSON ML
Citation
Ls. Snyder et al., CYCLOPHOSPHAMIDE-INDUCED HEPATOTOXICITY IN A PATIENT WITH WEGENERS GRANULOMATOSIS, Mayo Clinic proceedings, 68(12), 1993, pp. 1203-1204
Citations number
8
Categorie Soggetti
Medicine, General & Internal
Journal title
Mayo Clinic proceedings → ACNP
ISSN journal
00256196
Volume
68
Issue
12
Year of publication
1993
Pages
1203 - 1204
Database
ISI
SICI code
0025-6196(1993)68:12<1203:CHIAPW>2.0.ZU;2-8
Abstract
Cyclophosphamide is widely used in the treatment of many vasculitides. Hepatotoxicity associated with such therapy is uncommon but possible. Herein we describe a well-substantiated case of cyclophosphamide-indu ced hepatotoxicity in a patient with Wegener's granulomatosis. Physici ans should be aware of this potentially serious reaction when cyclopho sphamide therapy is initiated. Baseline liver function tests and perio dic assessment are recommended during treatment with cyclo-phosphamide .