HOW ALPHA-BETA-T-CELL RECEPTORS SEE PEPTIDE MHC COMPLEXES

Authors
CHIEN YH DAVIS MM
Citation
Yh. Chien et Mm. Davis, HOW ALPHA-BETA-T-CELL RECEPTORS SEE PEPTIDE MHC COMPLEXES, Immunology today, 14(12), 1993, pp. 597-602
Citations number
56
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
14
Issue
12
Year of publication
1993
Pages
597 - 602
Database
ISI
SICI code
0167-5699(1993)14:12<597:HARSPM>2.0.ZU;2-2
Abstract
Recent results hate added new information to our understanding of alph abeta T-cell receptor mediated recognition. In particular, we find tha t the V(D)J junction or 'CDR3' portion of TCRalpha and beta seem most important in contacting peptides bound to MHC molecules, consistent wi th previous predictions. Surprisingly, these same CDR3-peptide contact s also appear to have a major influence on the TCR-MHC molecule intera ctions as well.