ROLE OF THE 2ND MESSENGERS IN MODULATION OF CHOLINORECEPTORS PLASTICITY OF HELIX RPA3 NEURON BY OPIATE KAPPA-AGONIST BREMAZOCINE

In the paper was shown the participation of some second messengers in intracellular molecular mechanism of a decrease of RPa3 neuron cholino receptor plasticity by opiate kappa-agonist bremazocine during rhytmic al acetylcholine application. This mechanism includes 1) inhibition of inositol-1,4,5 trisphosphate-dependent mobilization of depoted Ca2+ a ctivating intracellular receptor calmodulin and 2) inhibition of the s ynthesis of the acyclic eicosanoids. It is possible to assume a specif icity of this mechanism, so far as is not revealed the role of the sec ond messengers under study in bremazocine inhibitors of RPa3 neuron so matic cholinoreceptors under the conditions of non-rhythmical acetylch oline application.