LONG-TERM-MEMORY AND LEARNING-ABILITY IN RATS WITH HIGH BRAIN SEIZUREACTIVITY AFTER ALLOTRANSPLANTATION OF EMBRYONIC NERVE-TISSUE

Fragments of the embrionic hippocampus, septum, cerebellum and substan tia nigra were grafted into the lesioned brain areas of 151 animals wi th phenotypical (bilateral destruction of the CA1 and CA4 hippocampal areas or the basolateral amygdalar regions in Wistar rats) and genotyp ical (in Krushinsky-Molodkina strain) high seisure readiness. The para meters of long-term memory were improved after embrionic septal and ce rebellar graftings, normalized after embrionic hippocampal graftings a nd were not improved after embrionic nigral graftings in both strains. Learning ability of the animals of both the strains with ceased audio genic seizures was kept at the control level after the transplantation of embrionic tissue from the different brain areas. In animals with c ontinued seizures the learning ability normalized after the septal gra ftings.