IN-VITRO EVIDENCE OF DELAYED-TYPE HYPERSENSITIVITY TO HYDROCORTISONE

Authors
WILKINSON SM ENGLISH JSC MATTEY DL
Citation
Sm. Wilkinson et al., IN-VITRO EVIDENCE OF DELAYED-TYPE HYPERSENSITIVITY TO HYDROCORTISONE, Contact dermatitis, 29(5), 1993, pp. 241-245
Citations number
26
Categorie Soggetti
Allergy,"Dermatology & Venereal Diseases
Journal title
Contact dermatitis → ACNP
ISSN journal
01051873
Volume
29
Issue
5
Year of publication
1993
Pages
241 - 245
Database
ISI
SICI code
0105-1873(1993)29:5<241:IEODHT>2.0.ZU;2-0
Abstract
Hypersensitivity to topical hydrocortisone is becoming increasingly re cognized. We present further evidence that this is mediated via a dela yed-type hypersensitivity reaction. A hydrocortisone: albumin complex was able to induce a proliferative response in the peripheral blood mo nonuclear cells of patients allergic to hydrocortisone. Protein bindin g of hydrocortisone or a degradation product may be important in the d evelopment of corticosteroid allergy.