INTERACTION OF DIETARY-PROTEIN AND FAT ON PLASMA-CHOLESTEROL AND AMINO-ACID LEVELS, FATTY-ACID DESATURATION, AND PROSTACYCLIN PRODUCTION INEXOGENOUS HYPERCHOLESTEROLEMIC RATS

Authors
IKEDA A IMAIZUMI K SUGANO M
Citation
A. Ikeda et al., INTERACTION OF DIETARY-PROTEIN AND FAT ON PLASMA-CHOLESTEROL AND AMINO-ACID LEVELS, FATTY-ACID DESATURATION, AND PROSTACYCLIN PRODUCTION INEXOGENOUS HYPERCHOLESTEROLEMIC RATS, Bioscience, biotechnology, and biochemistry, 57(11), 1993, pp. 1867-1872
Citations number
28
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
57
Issue
11
Year of publication
1993
Pages
1867 - 1872
Database
ISI
SICI code
0916-8451(1993)57:11<1867:IODAFO>2.0.ZU;2-F
Abstract
The interaction of dietary protein, casein (CAS) or soybean protein (S OY), and fats (perilla oil high in alpha-linolenic acid or safflower o il high in linoleic acid) on various lipid parameters and plasma amino acids was studied in a rat model sensitive to dietary cholesterol (ex ogenous hypercholesterolemic (ExHC) rats). The hypolipidemic effect of SOY in comparison with that of CAS was confirmed in this model irresp ective of the fat source. Thus, the hypocholesterolemic effect of SOY appeared to be intrinsic. However, the effects of dietary protein on t he fatty acid composition of tissue phospholipids, DELTA6 desaturase a ctivity in liver microsomes and aortic prostacyclin production were ma rginal. An analysis of plasma amino acids suggests a regulatory role o f specific amino acid(s) in the hypocholesterolemic effect of SOY.