Hg. Cutler et al., BOTCINOLIDE - A BIOLOGICALLY-ACTIVE NATURAL PRODUCT FROM BOTRYTIS-CINEREA, Bioscience, biotechnology, and biochemistry, 57(11), 1993, pp. 1980-1982
A novel biologically active natural product was isolated from a strain
of Botrytis cinerea found on cultivated raspberry fruit (Rubus ideaus
) upon fermentation in a liquid medium. Following a bioassay-directed
purification process, the final product was an amorphous solid with th
e molecular formula C20H34O8, and is trivially named botcinolide. It s
ignificantly inhibited etiolated wheat coleoptile growth at 10(-3) and
10(-4) M by 100 and 82% respectively, relative to the controls. Green
house-grown bean, corn, and tobacco plants were affected by treating w
ith botcinolide, and exhibited chlorosis and severe necrosis at 10(-2)
and 10(-3) M. The structure is a new hydroxylated nonalactone that is
esterified with 4-hydroxy-2-octenoic acid.