DO CALCIUM-INDUCED CALCIUM-RELEASE AND CALCIUM-PUMP COOPERATE TO GENERATE SPONTANEOUS OSCILLATION OF MEMBRANE CURRENT IN MAMMALIAN NEURONS

Authors
NISHIMURA T AKASU T
Citation
T. Nishimura et T. Akasu, DO CALCIUM-INDUCED CALCIUM-RELEASE AND CALCIUM-PUMP COOPERATE TO GENERATE SPONTANEOUS OSCILLATION OF MEMBRANE CURRENT IN MAMMALIAN NEURONS, Biomedical research, 14, 1993, pp. 39-41
Citations number
3
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Biomedical research → ACNP
ISSN journal
03886107
Volume
14
Year of publication
1993
Supplement
2
Pages
39 - 41
Database
ISI
SICI code
0388-6107(1993)14:<39:DCCACC>2.0.ZU;2-8
Abstract
Spontaneous rhythmic outward current (Iso) was recorded from the rabbi t parasympathetic neurons, using a single electrode voltage clamp tech nique. Removal of external calcium or internal load of calcium chelato r eliminated the Iso. External magnesium modulated the frequency of th e Iso. Cyclopiazonic acid and thapsigargin blocked the Iso. Ryanodine and procaine also blocked the Iso. Caffeine increased the frequency of the Iso. These data suggest that the magnesium-sensitive calcium-infl ux, the calcium-induced calcium release from the intracellular calcium stores and the calcium sequestration by the calcium-pump cooperate to the generation of the Iso.