CHRONIC MULTIFOCAL NEUROPATHY WITH PERSISTENT CONDUCTION BLOCK (LEWIS-SUMNER SYNDROME) - A CLINICO-MORPHOLOGIC STUDY OF 2 FURTHER CASES WITH REVIEW OF THE LITERATURE

We present data of 2 patients suffering from chronic motor-sensory mul tifocal neuropathy with persistent conduction block. The first case co ncerns a 9-year follow-up of a female, aged 24 years at onset with per sistent multiple conduction blocks and a tendency towards generalizati on of clinical deficits. Eight years after onset sural nerve biopsy re vealed extreme interfascicular variations of de/remyelination, onion b ulb formation, fiber loss, edema, and proliferation of basal lamina of endoneurial capillaries. Serum antibodies against GM1 gangliosides we re not detected. The second case, a 29-year-old Yemenitic male with a 5-year history, exhibited conduction blocks in motor and sensory fiber s, and a normal sural nerve biopsy. Our results are discussed with res pect to those of some 30 cases individually reported in the literature .