Sb. Mallory et al., TOPICAL LIDOCAINE FOR ANESTHESIA IN PATIENTS UNDERGOING PULSED DYE-LASER TREATMENT FOR VASCULAR MALFORMATIONS, Pediatric dermatology, 10(4), 1993, pp. 370-375
Pulsed dye laser treatment of vascular malformations is moderately pai
nful. Twenty-five percent lidocaine in 70% dimethyl sulfoxide-ethanol
was used to achieve anesthesia in patients undergoing the procedure. T
hirteen of 14 patients had some degree of anesthesia (average of 51%)
ranging from 10% to 100%, with 8 of them experiencing good results (>5
0% anesthesia). Diminishment of pain was assessed by comparison of las
er therapy on lidocaine-treated versus untreated sites within the vasc
ular malformation using verbal and visual analog scales. in vitro perm
eation demonstrated good absorption of lidocaine, peaking at one hour.
Permeation of lidocaine was significantly greater then that observed
from acid mantle cream or EMLA. Topical lidocaine at 25% concentration
in dimethyl sulfoxide 70% was well tolerated and had no side effects
except transient mild erythema.