EFFICACY OF BROMOCRIPTINE ADMINISTRATION FOR SELECTIVE PITUITARY RESISTANCE TO THYROID-HORMONE

The relation between thyroid-stimulating hormone (TSH) and triiodothyr onine (T3) was evaluated in a girl with the selective pituitary type o f thyroid hormone resistance for more than 7 years to clarify whether bromocriptine was an effective treatment or not. Levels of T3 (before: 2.44 +/- 0.64 nmol/l, mean +/- SD) and TSH (4.81 +/- 2.52 mU/l) were significantly decreased during therapy (T3: 2.15 +/- 0.44 nmol/l; TSH: 1.59 +/- 0.78 mU/1). T3 x TSH, calculated as one of the indices of pi tuitary resistance, on bromocriptine therapy (3.229 +/- 1.255 mU/l x n mol/l) was significantly (p < 0.005) smaller than the product before t he administration (11.298 +/- 5.891 mU/l x nmol/l). The results sugges t that bromocriptine should be one of the agents initially considered for the treatment of pituitary resistance to thyroid hormone.