HYPOTHYROID HYPERTROPHIC MYOPATHY OR HOFF MANN SYNDROME AS A COMPLICATION OF CHRONIC LYMPHOCYTIC THYROIDITIS - A CASE-REPORT

The authors report a case of hypothyroid hypertrophic myopathy which r eveal chronic lymphocytic thyroiditis. This entity est uncommon, can b e the most important sign of hypothyroidism and cure after the institu tion of thyroid hormone replacement therapy. The E. M. G. is usually m yopathic and serum muscle markers (myoglobin and enzymes) increased. P athologic studies of muscle show caracteritic but non specific and inc onstant abnormalities. Hypothyroid myopathy could be caused by a mitoc hondrial oxidative phosphorylation deficiency or changes in muscle con tractile properties (both in fibre type proportion and in the properti es of the muscle contractile proteins).