A URETERAL SMALL-CELL CARCINOMA MIXED WITH MALIGNANT MESODERMAL AND ECTODERMAL ELEMENTS - A CLINICOPATHOLOGICAL, MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY

A 60-year-old male with a small cell carcinoma of the right lower uret er is presented. The tumor mainly comprised a small cell carcinoma but also included a full variety of histological types such as transition al cell carcinoma, squamous cell carcinoma, adenocarcinoma, leiomyosar coma and chondrosarcoma. Immunohistochemical staining was positive for neuron specific enolase and cluster 1 small cell lung cancer antigen/ N-CAM in the small cell carcinoma and S-100 in the chondrosarcoma comp onent. The patient underwent a right nephroureterectomy, and received prophylactic radiation of the pelvic and para-aortic lymph node region s and cisplatin and etoposide combination chemotherapy. Eight months a fter the chemotherapy, a transitional cell carcinoma was found in the bladder neck, and a cystectomy with urethrectomy performed. To our kno wledge, this is the second report of a small cell carcinoma originatin g from the ureter.