CARDENOLIDE GLYCOSIDES WITH DOUBLY LINKED SUGARS FROM GOMPHOCARPUS-SINAICUS

Five cardenolide glycosides and two genins, including two new glycosid ic compounds, have been isolated for the first time from the chlorofor mic fraction of 70% ethanolic extract of powdered stems of Gomphocarpu s sinaicus Boiss. by preparative HPLC. The genins xysmalogenin and uza rigenin and the glycosides calotropin, 5,6-dehydrocalotropin, 3'-epi-a froside, 14beta,17alpha-epoxy-5,6-dehydrocalotropin and 15beta-hydroxy calotropin, were identified by 400 MHz H-1 and C-13 NMR, and EI-mass s pectra. The last two compounds are new compounds not previously isolat ed from a natural source.