Objectives: To fuel advocacy for improved health care for mentally ill
persons, the authors reviewed the literature that describes excess mo
rtality and underrecognition and undertreatment of comorbid medical co
nditions in this population. Barriers to optimal primary medical care
for psychiatric patients are discussed. Methods: A MEDLINE search focu
sing on mortality rind medical problems in psychiatric patients yielde
d 66 papers in English published between 1934 and 1996. These studies
and a German paper from 1912 are included in the review. Results and C
onclusions: Standardized mortality ratios for psychiatric patients, de
rived from comparisons with the general population and matched control
groups, have repeatedly demonstrated excess mortality from both natur
al and unnatural causes among psychiatric patients. Several large stud
ies that have attempted to clarify the issues underlying increased dea
th rates are discussed. Although no single diagnostic group emerges as
being at particularly high risk, substance abuse disorders alone or i
n combination with other psychiatric disorders have been repeatedly fo
und to lend to increased mortality rates. Other studies have also repe
atedly demonstrated that psychiatric patients suffer a high rate of co
morbid medical illnesses, which are largely undiagnosed and untreated
and which may cause or exacerbate psychiatric symptoms. Atypical prese
ntations are common, and changes in vision are the symptoms most predi
ctive of medical illness. Elderly patients and those with diagnoses of
organic brain syndromes are at highest risk for comorbid medical illn
ess. Parity in the medical and mental health treatment of psychiatric
patients requires both political advocacy and development of primary c
are programs capable of efficiently meeting their needs.