TOTAL SYNTHESIS OF (+)-PIPERAZINOMYCIN

Authors
BOGER DL ZHOU JC
Citation
Dl. Boger et Jc. Zhou, TOTAL SYNTHESIS OF (+)-PIPERAZINOMYCIN, Journal of the American Chemical Society, 115(24), 1993, pp. 11426-11433
Citations number
58
Categorie Soggetti
Chemistry
Journal title
Journal of the American Chemical Society → ACNP
ISSN journal
00027863
Volume
115
Issue
24
Year of publication
1993
Pages
11426 - 11433
Database
ISI
SICI code
0002-7863(1993)115:24<11426:TSO(>2.0.ZU;2-0
Abstract
A concise total synthesis of (+)-piperazinomycin (1), a novel naturall y occurring macrocyclic piperazine possessing antimicrobial and antifu ngal activity, is detailed with implementation of an improved Ullmann macrocyclization reaction conducted on a diketopiperazine (53%)