SYNTHESIS OF CYCLOPENTANE SPIROHYDANTOINS BY ALDOL CYCLIZATIONS - AN APPROACH TO HIGHLY SUBSTITUTED ALPHA-CYCLOPENTANE AMINO-ACIDS

Authors
FAIRBANKS AJ ELLIOTT RP SMITH C HUI A WAY G STORER R TAYLOR H WATKIN DJ WINCHESTER BG FLEET GWJ
Citation
Aj. Fairbanks et al., SYNTHESIS OF CYCLOPENTANE SPIROHYDANTOINS BY ALDOL CYCLIZATIONS - AN APPROACH TO HIGHLY SUBSTITUTED ALPHA-CYCLOPENTANE AMINO-ACIDS, Tetrahedron letters, 34(49), 1993, pp. 7953-7956
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
49
Year of publication
1993
Pages
7953 - 7956
Database
ISI
SICI code
0040-4039(1993)34:49<7953:SOCSBA>2.0.ZU;2-O
Abstract
Efficient but reversible aldol condensations of 2-azido-5-formyl-1,5-l actones provide short routes to precursors for alpha-cyclopentane amin o acids, some aminopseudosugars and spirohydantoins of cyclopentanes w ith control of the stereochemistry at all 5 carbons bearing functional groups. The effects of some of the compounds on human liver glycosida ses are described.