1. A selective dopamine DA1 receptor agonist, SKF38393, reduced the se
verity of experimentally-induced gastritis in rats. 2. This is the fir
st such demonstration with a dopamine DA1 receptor agonist. 3. When co
nsidered together with other reported actions of D1/DA1 receptor agoni
sts, these data confirm a significant gastroprotective role for dopami
ne.