COMORBIDITY MEASURES FOR STROKE OUTCOME RESEARCH - A PRELIMINARY-STUDY

Objective: To develop standardized comorbidity measures for use in str oke outcome research. Design: Retrospective review of medical records to analyze comorbidities and to study reliability and validity of the newly developed measures, comorbidity index (CI), and weighted comorbi dity index (w-CI). Setting: Tertiary rehabilitation center in Japan. P atients: 106 stroke patients, age 56.5 +/- 13.2yr, admitted and discha rged during the year from May 1994 to December 1995. The median days o f duration of stroke, onset to admission, and length of stay (LOS) wer e 199, 83, and 105.5, respectively. The median admission and discharge Functional Independence Measure (FIM) raw scores were 85 and 110, res pectively. Main Outcome Measures: Assessment of interrater reliability with intraclass correlation coefficient (ICC) for total scores and we ighted kappa for subscores; assessment of concurrent validity by relat ing the measures to Charlson's comorbidity index, total numbers of med ications, laboratory studies, therapeutic interventions, consultations , and days of interruption (Spearman's rank correlation method); study of predictive validity with discharge FIM score and LOS as dependent variables. Results: The ICCs were .896 for CI and .997 for w-CI, and w eighed kappa ranged from .615 to 1.00. CI and w-CI correlated signific antly with Charlson index and the above indices of validity. They also correlated negatively with discharge FIM scores and positively with L OS. With stepwise multiple regression analysis, 79.8% of the variance of discharge FIM scores could be explained by w-CI, days from onset to admission, admission FIM score, and deviation in tape bisection task. Conclusion: The newly developed comorbidity measures are reliable and valid for use in stroke outcome research. (C) 1997 bg the American Co ngress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation.