Jk. Elmquist et al., INDUCTION OF FOS-LIKE IMMUNOREACTIVITY IN THE RAT-BRAIN FOLLOWING PASTEURELLA-MULTOCIDA ENDOTOXIN ADMINISTRATION, Endocrinology, 133(6), 1993, pp. 3054-3057
The functional neuroanatomy of the immune system link to the CNS was i
nvestigated by assessing neuronal activity with Fos immunohistochemist
rY following systemic lipopolysaccharide (LPS) administration. Two hou
rs after LPS robust Fos-like immunoreactivity (Fos-IR) was observed in
several nuclear groups in the brain including the paraventricular and
supraoptic nuclei of the hypothalamus, central nucleus of the amygdal
a, and nucleus of the solitary tract. A similar but diminished pattern
of Fos-IR was present at 6 hours and was absent 24 hours after LPS ad
ministration. Investigation of the functional neuroanatomy of the acut
e phase reaction could prove to be critical in enhancing the ability o
f individuals to combat insults such as tissue damage and inflammation
.