EXCLUDING BLOOD-DONORS AT HIGH-RISK OF HIV-INFECTION IN A WEST-AFRICAN CITY

Objective-To examine the potential impact of deferral of blood donors at high risk of HIV infection in a west African city where blood is sc reened for HIV antibodies but no other special measures are taken to p rotect the blood supply.Design-Cross sectional study. Setting-National Blood Transfusion Centre and Project RETRO-CI, an international colla borative AIDS research project, Abidjan, Cote d'Ivoire. Subjects-1257 male first time blood donors. Interventions-Blood donors were intervie wed about demographic and behavioural characteristics and tested for H IV antibodies by enzyme immunoassay and, if positive, synthetic peptid e based tests. Main outcome measures-HIV antibody status in relation t o presence of behavioural risk factors; calculation of sensitivity, sp ecificity, and predictive values of specific criteria for excluding HI V infected donors. Results-The overall prevalence of HIV infection was 11.4%. The most important risk factors for HIV positivity were prosti tute contact and being aged 30-39 years. For identifying seropositive donors individual criteria had sensitivity, specificity, and positive predictive values ranging from 15% to 98%, 38% to 91%, and 17% to 30% respectively. Prostitute contact in the past five years would have exc luded 31% of all donors and 73% of HIV infected donors. 27% of those e xcluded would have been HIV positive. Conclusions--The widespread assu mption that donor deferral is not feasible in sub-Saharan Africa needs reassessment. In Abidjan this approach was well accepted and potentia lly effective. Donor deferral requires evaluation as a strategy for im proving blood safety in resource poor areas with high rates of HIV inf ection.