EXPRESSION OF ANTIGEN-CD18, ANTIGEN-CD11B , ANTIGEN-CD4, ANTIGEN-CD8,ANTIGEN-CD3 DETECTABLE BY MONOCLONAL-ANTIBODIES ICO IN BLOOD OF HEMOBLASTOSIS PATIENTS

CD18-positive cells (beta-chain of antigen LFA-1), cells CD11b+, CD4+, CD8+ and CD3+ were quantified in the blood of 32 acute leukemia patie nts, 38 chronic lymphoid leukemia patients and 15 mature-cell lymphosa rcoma patients. A standard reaction of indirect immunofluorescence was employed using ICO monoclonal antibodies. Alterations in the content and in the proportions of the main effector populations in the periphe ral blood of hemoblastosis patients were observed. These were more app arent in the unfavourable course of acute leukemia and in chronic lymp hoid leukemia. The detect was more marked in CD18+ and CD11b+ cells ex pressing antigen LFA-1. Reduced expression of LFA-1 considerably contr ibutes to impairment of antitumor resistance in hemoblastosis.