MARKOV-PROCESSES FOR MODELING AND ANALYZING A NEW GENETIC-MAPPING METHOD

Authors
FEINGOLD E
Citation
E. Feingold, MARKOV-PROCESSES FOR MODELING AND ANALYZING A NEW GENETIC-MAPPING METHOD, Journal of Applied Probability, 30(4), 1993, pp. 766-779
Citations number
11
Categorie Soggetti
Statistic & Probability","Statistic & Probability
Journal title
Journal of Applied Probability → ACNP
ISSN journal
00219002
Volume
30
Issue
4
Year of publication
1993
Pages
766 - 779
Database
ISI
SICI code
0021-9002(1993)30:4<766:MFMAAA>2.0.ZU;2-4
Abstract
This paper describes a set of stochastic processes that is useful for modeling and analyzing a new genetic mapping method. Some of the proce sses are Markov chains, and some are best described as functions of Ma rkov chains. The central issue is boundary-crossing probabilities, whi ch correspond to p-values for the existence of genes for particular tr aits. The methods elaborated by Aldous (I 989) provide very accurate a pproximate p-values, as spot-checked against simulations.