IMMOBILIZATION OF BIOACTIVE SUBSTANCES ON POLY(ALKYLENE PHOSPHATE)S .1. IMMOBILIZATION OF 2-PHENYLETHYLAMINE

Poly(alkylene phosphate)s of low molecular weight were synthesized by polytransesterification of dialkyl phosphonates with poly(ethylene gly col)s (PEG). These poly(alkylene phosphonate)s were then converted int o poly(alkylene phosphate)s by using the Atherton-Todd reaction in met hanol as a solvent. The compound 2-phenylethylamine was immobilized on these polymers via ionic bonds. These immobilizations were achieved b y both alkylation and dealkylation reactions. The final products from these reactions are the polyanions. The structures of these products w ere determined by a combination of H-1, P-31 and C-14 NMR spectroscopy .