INTRAATRIAL CALCIUM INFUSIONS, GROWTH, AND DEVELOPMENT IN END-ORGAN RESISTANCE TO VITAMIN-D

A five and a half year follow up of a girl with end organ resistant ri ckets is described. After failing to respond to high dose oral alfacal cidol (4 mu g/kg/day) and calcium supplements, treatment for one year with domiciliary intra-atrial calcium infusions at 2 years of age indu ced a complete remission, which was maintained on subsequent high dose oral calcium supplement. Overnight infusions were well tolerated with out adverse cardiovascular or renal sequelae or ectopic calcification. If the first three years of life are survived, the prognosis for a no rmal life on oral treatment is excellent.