ANAPHYLACTIC REACTION WITH CORONARY SPASM DURING CORONARY ARTERIOGRAPHY

The authors report a case of anaphylactic shock following the injectio n of iodinated contrast medium for coronary angiography and complicate d by two spasms affecting segments II and III of the right coronary. V asospasm was relieved by the injection of linsidomine, revealing an an giographically healthy segment III. Such complications associated with various substances, notably iodinated contrast media, are rare. They should nevertheless always be borne in mind when evaluating anaphylact ic type reactions. Vasoactive mediators (histamine, serotonin, arachid onic acid metabolites) released by the allergic reaction appear to pla y a major role. Treatment based upon pathogenesis can be proposed.