ACTION OF TOOSENDANIN ON THE MEMBRANE CURRENT OF MOUSE MOTOR-NERVE TERMINALS

Authors
XU YF SHI YL
Citation
Yf. Xu et Yl. Shi, ACTION OF TOOSENDANIN ON THE MEMBRANE CURRENT OF MOUSE MOTOR-NERVE TERMINALS, Brain research, 631(1), 1993, pp. 46-50
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
631
Issue
1
Year of publication
1993
Pages
46 - 50
Database
ISI
SICI code
0006-8993(1993)631:1<46:AOTOTM>2.0.ZU;2-I
Abstract
By perineurial recording, the actions of toosendanin on three potassiu m currents and two calcium currents in the nerve terminal were observe d in the intercostal nerve triangularis stein muscle of the mouse. Too sendanin partially blocked the voltage-dependent fast K+ current and i rreversibly increased the voltage-dependent slow Ca2+ current. The inc rease in the Ca2+ current of the nerve terminal accounts for the facil itation of transmitter release and the antibotulismic effect of toosen danin.