BENZODIAZEPINES ANTAGONIZE CENTRAL CORTICOTROPIN-RELEASING HORMONE-INDUCED SUPPRESSION OF NATURAL-KILLER-CELL ACTIVITY

Authors
IRWIN M HAUGER RL BRITTON K
Citation
M. Irwin et al., BENZODIAZEPINES ANTAGONIZE CENTRAL CORTICOTROPIN-RELEASING HORMONE-INDUCED SUPPRESSION OF NATURAL-KILLER-CELL ACTIVITY, Brain research, 631(1), 1993, pp. 114-118
Citations number
45
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
631
Issue
1
Year of publication
1993
Pages
114 - 118
Database
ISI
SICI code
0006-8993(1993)631:1<114:BACCH>2.0.ZU;2-6
Abstract
Benzodiazepines have anxiolytic properties and attenuate behavioral st ress responses induced by corticotropin releasing hormone (CRH). To ev aluate the effect of benzodiazepines on CRH-induced immune suppression , potent centrally acting benzodiazepines were administered prior to c entral infusion of CRH (i.c.v.; 1.0 mu g). CRH induced a significant ( P < 0.01) reduction of splenic natural killer cell activity which was completely antagonized by pretreatment with either diazepam or alprazo lam.