ELECTROPHORETICALLY DEFINED MYOSIN HEAVY-CHAIN PATTERNS OF SINGLE HUMAN MUSCLE-SPINDLES

Authors
PEDROSADOMELLOF F GOHLSCH B THORNELL LE PETTE D
Citation
F. Pedrosadomellof et al., ELECTROPHORETICALLY DEFINED MYOSIN HEAVY-CHAIN PATTERNS OF SINGLE HUMAN MUSCLE-SPINDLES, FEBS letters, 335(2), 1993, pp. 239-242
Citations number
22
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
335
Issue
2
Year of publication
1993
Pages
239 - 242
Database
ISI
SICI code
0014-5793(1993)335:2<239:EDMHPO>2.0.ZU;2-8
Abstract
At least four myosin heavy chain (MHC) isoforms were separated by SDS- PAGE in extracts of intrafusal fibers isolated by microdissection from human lumbrical muscles. The fastest migrating MHC represents a slow isoform. The slowest migrating MHC was identified as the embryonic MHC (emb) A faint band, moving slightly faster than MHC(emb) most likely r epresents a neonatal/fetal MHC isoform. A prominent band, moving betwe en the latter and the slow isoform is suggested to represent a hithert o unidentified, spindle-specific MHC isoform, MHC(if).