THE ROLE OF APOPTOTIC AND NECROTIC PROCESSES IN CYTOLYSIS MEDIATED BYLAK CELLS WITH DIFFERENT PHENOTYPES

Authors
SASHCHENKO LP KABANOVA OD BLISHCHENKO LY LUKJIANOVA TI SATPAEV DK CHERTOV OY GNUCHEV NV
Citation
Lp. Sashchenko et al., THE ROLE OF APOPTOTIC AND NECROTIC PROCESSES IN CYTOLYSIS MEDIATED BYLAK CELLS WITH DIFFERENT PHENOTYPES, FEBS letters, 335(2), 1993, pp. 270-272
Citations number
15
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
335
Issue
2
Year of publication
1993
Pages
270 - 272
Database
ISI
SICI code
0014-5793(1993)335:2<270:TROAAN>2.0.ZU;2-M
Abstract
The role of necrotic and apoptotic pathways in cytolysis mediated by L AK cells was studied. The contribution of necrotic and apoptotic proce sses to cytolysis depends both on the LAK cells' phenotype and the typ e of target cells. CD16+/CD8+/CD3- LAK cells induced necrosis of K562 and L929 target cells. The cell death induced by CD3+/CD8+/CD16- LAK c ells was found to include features of apoptotic and necrotic processes .