SYNTHESIS AND SPECTROSCOPIC PROPERTIES OF C-13- AND N-15-LABELED TERT-BUTOXYCARBONYLGLYCINES

Three C-13-labelled bromoacetates have been reacted both with N-15-lab elled and with unlabelled di-tert-butyl imidodicarbonate and the inter mediates selectively deprotected to give the corresponding isotopomeri c Boc-glycines for application in peptide synthesis. The products were characterized by H-1, C-13 and N-15 NMR and FT-IR spectroscopy. Isoto pe effects on chemical shifts and IR spectra for this set of compounds are tabulated. In addition, from three isotopomers N-15-labelled amid es were also prepared.