REVERSAL OF MULTIDRUG-RESISTANCE TO CANCER-CHEMOTHERAPY

Authors
LEYLANDJONES B DALTON W FISHER GA SIKIC BI
Citation
B. Leylandjones et al., REVERSAL OF MULTIDRUG-RESISTANCE TO CANCER-CHEMOTHERAPY, Cancer, 72(11), 1993, pp. 3484-3488
Citations number
31
Categorie Soggetti
Oncology
Journal title
Cancer → ACNP
ISSN journal
0008543X
Volume
72
Issue
11
Year of publication
1993
Supplement
S
Pages
3484 - 3488
Database
ISI
SICI code
0008-543X(1993)72:11<3484:ROMTC>2.0.ZU;2-D
Abstract
In the past few years, the role of membrane-bound transport genes in h uman disease has been increasingly recognized and understood. Of these genes, the p170 membrane glycoprotein may function as an outward tran sport pump for many cancer chemotherapeutic drugs associated with the multidrug resistance phenotype. This article reviews the different cla sses of the current major modulators of multidrug resistance.