PHARMACOKINETICS OF CICLOPIROX OLAMINE AFTER VAGINAL APPLICATION TO RABBITS AND PATIENTS

The authors reported the plasma levels and pharmacokinetic parameters of ciclopirox olamine in rabbits after i.v. and intravaginal administr ations and in female patients after vaginal administration. Plasma lev els of total and free ciclopirox were determined by a HPLC method. In rabbit ciclopirox showed a half-life of 2.22 h and an intravaginal bio availability of about 2%. In female patients ciclopirox showed low int ravaginal absorption; this value might explain the good local and syst emic tolerability and also the penetration of drug in deep tissue.