Management of neonatal Hirschsprung's disease based on diagnosis by hi
stologic techniques and frozen section biopsy during colostomy is curr
ently the most acceptable method. However, the non-availability of his
tologic and histochemical techniques often necessitates alternate appr
oaches. In 376 infants below the age of 2 months who were admitted wit
h the presumptive diagnosis of Hirschsprung's disease, a barium enema
was the key investigation. Histologic confirmation could be obtained a
fter a colostomy was established. Manometry allowed the detection of a
ny diagnostic errors. The overall error rate was approximately 4%. An
alternate algorithm is suggested for the management of Hirschsprung's
Disease, particularly in less well-developed centers.