IN-VITRO ANTIBACTERIAL ACTIVITIES OF PD 138312 AND PD 140248, NEW FLUORONAPHTHYRIDINES WITH OUTSTANDING GRAM-POSITIVE POTENCY

PD 138312 and PD 140248 are new quinolones with high in vitro activiti es against a wide spectrum of bacterial species, notably including gra m-positive isolates. The respective MICs (in micrograms per milliliter ) of PD 138312 and PD 140248 capable of inhibiting greater than or equ al to 90% of the strains were less than or equal to 0.06 and less than or equal to 0.06 for oxacillin-susceptible and -resistant staphylococ ci, streptococci (including Streptococcus pyogenes, S. agalactiae, S. pneumoniae, and viridans group streptococci), Haemophilus influenzae, Moraxella catarrhalis, and Neisseria gonorrhoeae; 0.125 and 0.03 for L egionella pneumophila; 0.25 and 0.125 for Listeria monocytogenes; 0.25 and 0.25 for Enterococcus faecalis; 0.5 and 0.06 for anaerobic gram-p ositive cocci; 0.5 and 0.25 for Acinetobacter spp.; 0.5 and 0.5 for me mbers of the family Enterobacteriaceae (excluding Serratia marcescens) ; 2 and 0.5 for Bacteroides fragilis; 2 and 2 for Serratia marcescens and ciprofloxacin-resistant staphylococci; and 8 and 4 for Pseudomonas aeruginosa.