IN-VITRO ACTIVITY OF NOVOBIOCIN AGAINST MULTIRESISTANT STRAINS OF ENTEROCOCCUS-FAECIUM

Citation
P. French et al., IN-VITRO ACTIVITY OF NOVOBIOCIN AGAINST MULTIRESISTANT STRAINS OF ENTEROCOCCUS-FAECIUM, Antimicrobial agents and chemotherapy, 37(12), 1993, pp. 2736-2739
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
ISSN journal
00664804
Volume
37
Issue
12
Year of publication
1993
Pages
2736 - 2739
Database
ISI
SICI code
0066-4804(1993)37:12<2736:IAONAM>2.0.ZU;2-Y
Abstract
Sixty strains of vancomycin- and ampicillin-resistant Enterococcus fae cium were evaluated for their susceptibilities to novobiocin in vitro. In Mueller-Hinton broth, novobiocin inhibited all strains when it was used at a concentration of less than or equal to 2 mu g/ml and 40 of 60 strains when it was used at a concentration of less than or equal t o 0.5 mu g/ml. MICs were 8- to 16-fold higher in 50% serum. Novobiocin alone resulted in 2-log-unit killing at 24 h. Combinations of novobio cin and a fluoroquinolone (either ciprofloxacin or ofloxacin) were add itive and bactericidal for quinolone-susceptible strains in either bro th or 50% serum. Gentamicin did not affect novobiocin activity, and ri fampin and doxycycline were antagonistic.