ELECTROREDUCTION AND DETERMINATION OF PIPRIL (PIPERACILLIN) IN BOTH AQUEOUS AND BIOLOGICAL SAMPLES

The electrochemical behavior of the relatively new antibacterial antib iotic Pipril (Piperacillin) at the dropping mercury electrode is inves tigated using both direct current polarography (DCP) and differential pulse polarography (DPP). At the hanging mercury electrode (HMDE), the reduction mechanism has been elucidated using cyclic voltammetric tec hnique in the pH range from 2 to 10. The effect of some metal ions, e. g. Cu(II) and Pb(II) has been also tested. Determination of the drug u sing adsorptive stripping analysis was assessed in both aqueous and ur ine samples. The effect of the different experimental parameters affec ting the drug determination, e.g. pH, supporting electrolyte nature, a ccumulation potential, accumulation time and other operational paramet ers are also mentioned. Detection limits of 5 x 10(-9) and 1 x 10(-8) M Pipril in aqueous and urine samples, respectively, are achieved.