CHROMOSOME 4 LOCALIZATION OF A 2ND GENE FOR AUTOSOMAL-DOMINANT POLYCYSTIC KIDNEY-DISEASE

Autosomal dominant polycystic kidney disease (ADPKD) is a genetically heterogeneous disorder. A gene defect located on the short arm of chro mosome 16 is responsible for the disease in roughly 86% of affected Eu ropean families. Using highly polymorphic microsatellite DNA markers, we have assigned a second gene for ADPKD to chromosome 4. In eight fam ilies with clear evidence against linkage to chromosome 16 markers, li nkage analysis with the markers D4S231 and D4S423, demonstrated a mult ipoint rod score of 22.42.