Kd. Alahari et al., VITAMIN-D-RECEPTOR ALLELES DO NOT CORRELATE WITH BONE-MINERAL DENSITYIN PREMENOPAUSAL CAUCASIAN WOMEN FROM THE SOUTHEASTERN UNITED-STATES, Metabolism, clinical and experimental, 46(2), 1997, pp. 224-226
Genetic factors are important in determining peak bone density. Recent
studies indicate that polymorphisms of the vitamin D receptor (VDR) m
ay account for much of the genetic contribution to bone density, and V
DR genotype may be useful to predict the risk of developing osteoporos
is. However, the association between VDR genotype and bone mineral den
sity (BMD) has not been observed in all populations. We determined VDR
genotype in 69 healthy premenopausal Caucasion women from the southea
stern United States and measured BMD at the lumbar spine (anterior-pos
terior [AP] and lateral views) and proximal femur. We found no associa
tion between VDR genotype and BMD at any site. Our results indicate th
at in this population, VDR genotype does not predict peak bone density
and should not be used to predict the risk of developing osteoporosis
. Copyright (C) 1997 by W.B. Saunders Company.