GROWTH OF THE HUMAN OPTIC DISK AND NERVE DURING GESTATION, CHILDHOOD,AND EARLY ADULTHOOD

We measured vertical and horizontal diameters of the optic disk and re trobulbar optic nerve in eyes from 95 patients on whom autopsies were performed at the UCLA Medical Center over a 20-year period. Ages at de ath ranged from 4.8 months' gestation to 21.9 years. Optic disk surfac e area and nerve cross-sectional area were calculated for each subject by using the formula for an ellipse. Approximately 50% of the growth of the optic disk and nerve occurs by 20 weeks' gestation, and 75% by birth; 95% of the growth occurs before the age of 1 year. All optic di sk and nerve measurements correlate strongly (correlations > .67; P < .0001) with subject height and globe anteroposterior diameter. We appl ied our results to the current understanding of optic disk and nerve d evelopment, and compared them to previous clinical and pathologic stud ies of optic nerve dimensions in adults and older children.