AMINO-ACID-SEQUENCE OF GLUTATHIONE-S-TRANSFERASE A FROM GUINEA-PIG LIVER

Authors
KAMEIHAYASHI K OSHINO R HARA S
Citation
K. Kameihayashi et al., AMINO-ACID-SEQUENCE OF GLUTATHIONE-S-TRANSFERASE A FROM GUINEA-PIG LIVER, Journal of Biochemistry, 114(6), 1993, pp. 835-841
Citations number
39
Categorie Soggetti
Biology
Journal title
Journal of Biochemistry → ACNP
ISSN journal
0021924X
Volume
114
Issue
6
Year of publication
1993
Pages
835 - 841
Database
ISI
SICI code
0021-924X(1993)114:6<835:AOGAFG>2.0.ZU;2-6
Abstract
The amino acid sequence of glutathione S-transferase a from guinea pig liver was determined. Glutathione S-transferase a was composed of two identical subunits, each comprising 218 amino acid residues. The amin o acid sequence of glutathione S-transferase a exhibited 73% homology with that of human glutathione S-transferase Ha, 69% with that of rat glutathione S-transferase Ya, and 68% with that of rat glutathione S-t ransferase Yc, which are known to belong to class Alpha. From the abov e result, together with previous observations on its substrate specifi city, it was concluded that glutathione S-transferase a belonged to cl ass Alpha.