OCCUPATIONAL EXPOSURE TO ISOCYANATES AND INDIVIDUAL HYPERSENSITIVITY

Authors
BERODE M SAVOLAINEN H
Citation
M. Berode et H. Savolainen, OCCUPATIONAL EXPOSURE TO ISOCYANATES AND INDIVIDUAL HYPERSENSITIVITY, Sozial- und Praventivmedizin, 38, 1993, pp. 190000125-190000127
Citations number
NO
Categorie Soggetti
Public, Environmental & Occupation Heath
Journal title
Sozial- und Praventivmedizin → ACNP
ISSN journal
03038408
Volume
38
Year of publication
1993
Supplement
2
Pages
190000125 - 190000127
Database
ISI
SICI code
0303-8408(1993)38:<190000125:OETIAI>2.0.ZU;2-Q
Abstract
Patients with organic diisocyanate-induced pulmonary disease may be sp ecially susceptible to the toxic effects of agent. Among 11 cases diag nosed in one year, the majority (10/11)were slow acetylators. The same patients were different from the control population in terms of alpha -1-antitrypsin phenotypes. Heterozygous combinations were more frequen t than among controls. It seems that the combination of low N-acetylat ion capacity and a heterozygous alpha-1-antitrypsin predisposes to the disease.