While there are increasing demands for improved post-operative analges
ia and the implementation of Acute Pain Services (APS), the safety of
such an approach remains under discussion. This paper analyses the saf
ety outcome of 3016 consecutive post-operative patients treated under
the care of a formalised Acute Pain Service. No serious complication r
esulting in morbidity or mortality occurred. Potentially severe compli
cations without sequelae were discovered in 16 patients (0.53%); this
incidence was similar for techniques of systemic opioid administration
and continuous regional analgesia. Patient-controlled analgesia (PCA)
alone had a significantly lower rate of respiratory depression than P
CA with a background infusion or continuous morphine infusion. In 1069
patients receiving continuous regional analgesia (epidural, interpleu
ral, peripheral) no trauma to nervous structures, no infection and no
local anaesthetic toxicity occurred. In conclusion, an anaesthesiology
-based APS can provide postoperative pain relief using a wide range of
relatively invasive techniques without endangering patient safety.